Which statement about insulin glargine compatibility is correct?

Which statement about insulin glargine compatibility is correct?

• A. It can be mixed with rapid-acting insulin in the same syringe.
• B. It should be rolled before drawing up.
• C. It should be administered subcutaneously and not mixed with other insulins.
• D. It must be given intramuscularly.

Answer: (C)

Long-acting insulin glargine is used to provide a steady basal insulin level and is formulated for subcutaneous injection. It should not be mixed with other insulins in the same syringe because mixing can alter its time-action profile and dosing accuracy, potentially changing its efficacy and risk of hypoglycemia or hyperglycemia. It is also not given intramuscularly, since IM administration changes absorption and makes glucose control unpredictable. Glargine is a clear solution, so there’s no need to roll or agitate it before drawing up. For these reasons, the correct statement is that it should be administered subcutaneously and not mixed with other insulins.

Long-acting insulin glargine is used to provide a steady basal insulin level and is formulated for subcutaneous injection. It should not be mixed with other insulins in the same syringe because mixing can alter its time-action profile and dosing accuracy, potentially changing its efficacy and risk of hypoglycemia or hyperglycemia. It is also not given intramuscularly, since IM administration changes absorption and makes glucose control unpredictable. Glargine is a clear solution, so there’s no need to roll or agitate it before drawing up. For these reasons, the correct statement is that it should be administered subcutaneously and not mixed with other insulins.